This collaborative project aims to establish a national computational resource to move the research community much closer to the realization of the goal of the Tree of Life initiative, namely, to reconstruct the evolutionary history of all organisms. This goal is the computational Grand Challenge of evolutionary biology. Current methods are limited to problems several orders of magnitude smaller, and they fail to provide sufficient accuracy at the high end of their range. The planned resource will be designed as an incubator to promote the development of new ideas for this enormously challenging computational task; it will create a forum for experimentalists, computational biologists, and computer scientists to share data, compare methods, and analyze results, thereby speeding up tool development while also sustaining current biological research projects. The resource will be composed of a large computational platform, a collection of interoperable high-performance software for phylogenetic analysis, and a large database of datasets, both real and simulated, and their analyses; it will be accessible through any Web browser by developers, researchers, and educators. The software, freely available in source form, will be usable on scales varying from laptops to high-performance, Grid-enabled, compute engines such as this project's platform, and will be packaged to be compatible with current popular tools. In order to build this resource, this collaborative project will support research programs in phyloinformatics (databases to store multilevel data with detailed annotations and to support complex, tree-oriented queries), in optimization algorithms, Bayesian inference, and symbolic manipulation for phylogeny reconstruction, and in simulation of branching evolution at the genomic level, all within the context of a virtual collaborative center. Biology, and phylogeny in particular, have been almost completely redefined by modern information technology, both in terms of data acquisition and in terms of analysis. Phylogeneticists have formulated specific models and questions that can now be addressed using recent advances in database technology and optimization algorithms. The time is thus exactly right for a close collaboration of biologists and computer scientists to address the IT issues in phylogenetics, many of which call for novel approaches, due to a combination of combinatorial difficulty and overall scale. The project research team includes computer scientists working in databases, algorithm design, algorithm engineering, and high-performance computing, evolutionary biologists and systematists, bioinformaticians, and biostatisticians, with a history of successful collaboration and a record of fundamental contributions, to provide the required breadth and depth. This project will bring together researchers from many areas and foster new types of collaborations and new styles of research in computational biology; moreover, the interaction of algorithms, databases, modeling, and biology will give new impetus and new directions in each area. It will help create the computational infrastructure that the research community will use over the next decades, as more whole genomes are sequenced and enough data are collected to attempt the inference of the Tree of Life. The project will help evolutionary biologists understand the mechanisms of evolution, the relationships among evolution, structure, and function of biomolecules, and a host of other research problems in biology, eventually leading to major progress in ecology, pharmaceutics, forensics, and security. The project will publicize evolution, genomics, and bioinformatics through informal education programs at museum partners of the collaborating institutions. It also will motivate high-school students and college undergraduates to pursue careers in bioinformatics. The project provides an extraordinary opportunity to train students, both undergraduate and graduate, as well as postdoctoral researchers, in one of the most exciting interdisciplinary areas in science. The collaborating institutions serve a large number of underrepresented groups and are committed to increasing their participation in research.
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TEAM MEMBERS:
Tandy WarnowDavid HillisLauren MeyersDaniel MirankerWarren Hunt, Jr.
The Education Development Center, Incorporated, requests $2,081,018 to create informal learning opportunities in science, mathematics, engineering and technology utilizing the study of the ancient African civilization of Nubia as context. Educational activities and resources will be developed based on the extensive ongoing archeological research on historical Nubia. The two main components of the project are a traveling exhibit with related educational materials and a website that will provide the target audience an opportunity to access extensive on-line resources and activities. The project will provide community outreach and professional development for educators in museums, community groups, schools and libraries. The project is designed for thirty-six months' duration. In year one, a network of collaborators in the Boston area will focus on research and development; in year two, project materials will be piloted and evaluated in six cities, and on-line professional development programs will be conducted; and in year three, project materials will be disseminated directly to 60 sites and more broadly via the internet.
Two 8 to 10 week modules, one focusing on cells and the other on reproduction and heredity, serve as the basis for the development of a comprehensive, assessment-driven, middle school science curriculum called "Science for Today and Tomorrow." A curriculum frramework is developed for Life and Physical Sciences to be taught in Grades 6 and 7 and Earth Science in Grade 8. The research-based materials assist students to develop a working knowledge of a core set of ideas that are fundamental to the discipline and ultimately to see how the concepts span the disciplines. The student materials and the teachers' guides are enhanced with classroom-tested assessments and web-based content resources, simulations and tools for gathering and interpreting data. On-line professional development materials allow teachers to gain content knowledge and pedagogical skills. The website also contains an area that provides information for administrators including strategies for supporting teachers and another area for community members to involve them in the students' science learning. The project builds upon the lessons learned in previous materials development projects at TERC.
The Tech Museum of Innovation is producing a 3,000 square-foot permanent exhibition, complementary online acitivities, and a Design Challenge curriculum to engage visitors in the exploration of Internet techologies. The goals of the project are to enhance the technological literacy of middle school students, provide the general public with tools, experience, and confidence to participate in shaping the future of the internet, and advance the informal science education community through applied research in networked exhibit technology. Two distinct features of the exhibit are: 1) The Smart Museum, a computer network linking gallery and online expereinces, and 2) "dynamic content," a set of strategies for rapid exhibit updates that will mirror the changing Internet for the life of the exhibition. The Design Challenge curriculum will be used at the museum, in outreach to classrooms and community centers, and in training sessions for science educators. The summative research will be shared with the science education community via The Tech's web site as well as professional seminars, publications and conferences.
Massachusetts General Hospital, representing Partners HealthCare System, Inc., is producing a large format film on the brain that is designed to increase the popular understanding of brain biology and recent advances in neuroscience. Framed within the larger question of the unique abilities of the human mind, the project will take an interdisciplinary look at brain science and raise questions about the nature and biological basis of diverse aspects of human experience including consciousness. By following a rider in the Tour de France, the film will illustrate how the brain functions in both normal and stressful situations. Major sequences will explore vision, memory and emotion. Slightly shorter sequences will delve into imagination and creativity, language, dreams and pain. Brief "interludes" will allow the film to reflect on the brain as it is represented in a range of human capabilities. Finally, the film turns it attention to consciousness, self-awareness and the totality of experiencing life as a human. Outreach components of the project include: A weeklong national symposium for museum educators, teachers, and community organizations from all regions of the country. Follow up regional "Brain Workshops" designed to provide more focused project support. "The Brain: Exploratory Trips Into the Final Frontier" -- An Educator/Student Activity Guide Fun Facts Family Guide to "The Brain" An Educational Lobby Kiosk "Head Trip: A Voyage Through the Young Human Mind" -- An illustrated instructional brochure A Brain Website The film will be directed by Bayley Silleck whose prior large format films include "Cosmic Voyage" and "Lost Worlds: Life in the Balance." The lead scientific advisors are Dr. Dennis Selkow, Professor of Neurology and Neuroscience at Harvard Medical School, and Dr. Anne Young, Julieanne Dorn Professor of Neurology at Harvard Medical School. There also will be a seven-member advisory committee composed of neuroscientists, psychologists and philosophers.
The Natural History of Museum of Los Angeles County will mount and administer a five (5) year tour of an exhibition, "Dogs: Our Canine Companions," which explores the evolution, behavior, diversity and cultural significance of dogs. Visitors to the 6,000 sq. ft. exhibit will gain a better knowledge of these familiar animals through a variety of componenets including hands-on displays, videos, graphic panels, computer-generated images, dioramas, fossil skeletons and educational curriculum materials. The exhibit will be divided into eight (8) sections. Throughout the sections there are recurring themes to unify the educational messages of the adaptive diversity of canids, the relationship between wild and domestic dogs, and the relationship between dogs and humans -- especially service dogs. The dissemination of DOGS will include presentations to groups and conferences, with particular emphasis on the exhibit's treatment of accessibility issues. There will be an extensive web site with animation, movies, sound and interactive elements to further enhance the effectiveness of the exhibit and the availability of educational materials. the final ancillary materials to accompany the traveling exhibition will be a theater production, a free-standing, self-contained learning center, an exhibit guide, and a CD-Rom. Formal education providers will benefit from workshops, curriculum guides, and teaching kits.
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TEAM MEMBERS:
Linda AbrahamBlaire Van ValkenburghRobert Wayne
WGBH is conducting preliminary work on an untested and novel idea for a new multimedia project, EGames. The target audience for the project is children ages 9-12. The project envisions a 13-part television series which combines the appeal of a game show with the drama of real-world challenges to engender enthusiasm and promote understanding of engineering in kids nationwide. The television programs will be complemented with materials and training for engineers to mount EGames events in public venues and run workshops in schools, afterschool programs and libraries, and an extensive companion website. During the research phase, WGBH will convene a Content Advisory Board which would include professional engineers, curriculum developers, classroom teachers, professors of engineering and informal educators, and a Funding Advisory Board. They will also write the series curriculum, design the game, develop outreach, Web, and evaluation plans, and develop and test a sample engineering challenge with a group of contestants to work out logistic and production questions. This will inform the next stage of project development. Note: This project led to the series "FETCH! With Ruff Ruffman."
Screenscope, Inc. is producing three annual "state of the environment" reports. The reports will consist of a yearly, ninety-minute, prime-time public television program and an extensive outreach initiative to engage families and the public in a variety of educational activities. The television programs will: Present an up-to-date "state of the environment" assessment of ecosystem performance and human health; Feature the year's most important environmental incidents; Highlight the year's most cutting-edge scientific breakthroughs and research dealing with environmental issues; Focus on community programs that have helped improve the quality of the environment over the past year. The outreach initiative will include: A Citizen Science Project with strong emphasis on family participation; Neighborhood workshops and coalitions organized by local PBS stations in association with the American Association for Advancement of Science and the World Resources Institute; An interactive web component including real-time environmental satellite data and visualizations; Local and national media events featuring the yearly release of a "State of the Environment" report; Partnerships will be developed with environmental organizations to help promote and implement the initiative's informal education activities. The project will be under the direction of Marilyn and Hal Weiner with the television programs being produced by their company, Screenscope. Anthony Janetos, Vice President and Chief of Programs at the World Resources Institute will have oversight responsibility for the science information presented in the Annual Report. Project advisors include: Bonnie Cohen, former Under Secretary of State for Management and Board member of CARE; Chet Cooper, former Deputy Director, Emerging Technologies, Battelle/Pacific Northwest National Laboratory; Robert Fri, Senior Fellow Emeritus at Resources for the Future and former Director of the National Museum of Natural History; Edward Frieman, Director Emeritus at of the Scripps Institution of Oceanography and Vice Chancellor of the University of California; Nay Htun, Dean of the University of Peace and former Assistant Secretary-General, United Nations Development Programme; Thomas Lovejoy, Science Advisor to the World Bank and the UN Foundation; Jessica Tuchman Mathews, President of the Carnegie Endowment for International Peace; Per Pinstrup-Andersen, Director-General, International Food Policy Research Institute; Maurice Strong, Chairman, Earth council and former Secretary-General of the United Nations Earth Summit in Rio de Janeiro. There also will be science advisors for each of the individual episodes.
National Geographic Television requests $1,121,583 (35%) of a total project budget of $3,192,249, to produce a documentary series in 13 half-hour and one hour-long special, "Facing the Wild: The Crittercam Chronicles," with associated informal science education materials and programs. This project will feature the natural histories of some of the Earth's most enigmatic and charismatic marine species, highlight the groundbreaking technology employed to study these extraordinary creatures and celebrate the scientists who devote their lives to understanding marine creatures. The project's goals include: to educate audiences about the vital importance of the world's oceans to the health of the planet; to celebrate the ingenuity of novel technology developed for science and exploration; to illustrate that many tantalizing mysteries remain yet unsolved and a great deal of exciting science and exploration has yet to be done; to provide viewers with scientific role models and help motivate them to pursue careers in science. Employing cutting-edge remote imaging tools, including "crittercam", and National Geographic's trademark storytelling, Facing the Wild's strong conservation message is designed to appeal to a national and global audience. A robust web site, virtual teacher workshops and Student Ocean Conferences will augment the impact of the series.
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TEAM MEMBERS:
Greg MarshallKeenan SmartBarbara Flagg
The Science Museum of Minnesota (SMM) in collaboration with the Illinois State Museum (ISM), the St. Louis Science Center (SLSC), and the National Center for Supercomputing Applications(NCSA) at the University of Illinois in Champaign, Illinois, will form a museum consortium to develop two virtual reality interactive displays (River Pilot Simulator and Digital River Basin) and other web-based activities that focus on the Mississippi River. This group will be known as the Mississippi River Web Museum Consortium. Each museum will end up with both software modules that will lead visitors to the story of the River. The river's local presence will serve as an entry point for the visitors at each museum. The NCSA will contribute their access to and knowledge of powerful computer simulation, scientific visualization, and collaborations technologies that are usually restricted to research settings and rarely available to a museum audience or the general public. The Consortium will also develop a shared site on the WWW that will invite users to engage in guided inquiry that will deepen their understanding of the large, complex, and integrated river system. The science content underlying the project will include river hydrology and geomorphology, life sciences, environmental studies employing geographic information systems, and the physics of motion. The activities will address a number of the National Science Education Standards. Complementary programming linking these activities with formal education include a RiverWeb(tm) Posting Board and a RiverWeb(tm) Classroom Resource Guide.
The Science Museum of Minnesota (SMM) in collaboration with the Illinois State Museum (ISM), the St. Louis Science Center (SLSC), and the National Center for Supercomputing Applications(NCSA) at the University of Illinois in Champaign, Illinois, will form a museum consortium to develop two virtual reality interactive displays (River Pilot Simulator and Digital River Basin) and other web-based activities that focus on the Mississippi River. This group will be known as the Mississippi River Web Museum Consortium. Each museum will end up with both software modules that will lead visitors to the story of the River. The river's local presence will serve as an entry point for the visitors at each museum. The NCSA will contribute their access to and knowledge of powerful computer simulation, scientific visualization, and collaborations technologies that are usually restricted to research settings and rarely available to a museum audience or the general public. The Consortium will also develop a shared site on the WWW that will invite users to engage in guided inquiry that will deepen their understanding of the large, complex, and integrated river system. The science content underlying the project will include river hydrology and geomorphology, life sciences, environmental studies employing geographic information systems, and the physics of motion. The activities will address a number of the National Science Education Standards. Complementary programming linking these activities with formal education include a RiverWeb(tm) Posting Board and a RiverWeb(tm) Classroom Resource Guide.
The Space Science Institute (SSI) seeks to develop the "Stardust Project," designed to introduce the public to concepts related to the birth of stars, the search for planets beyond our solar system and the search for life beyond earth. The project's three components include a 2,500 square-foot travelling exhibition called "Stardust: Our Search for Origins;" a comprehensive education program for museum staff and grades 4-9 school teachers and a public Web site that incorporates and builds on the exhibit and education content. The project proposes to assemble standards-based educational materials for dissemination through workshops conducted at museums that host the exhibit. The educational programs -- particularly professional development workshops for teachers -- target, among other groups, underserved Native American and Hispanic teachers associated with a partnership between SSI and the NSF Rural Systematic Initiatives in the American West. The project is built around strong partnerships with two NASA Origins Program missions and with established informal education institutions including the New York Hall of Science, the Lawrence Hall of Science, the Denver Museum of Nature and Science, TERC and the SETI Institute. Its goals are to make it possible for teachers, students and the public to learn about: The formation of stars, planets, and the solar system; The conditions necessary for life; The effect of life on Earth's environment; The methods used to detect planets orbiting distant stars and The scientific tools used in origin research -- from space-based telescopes to microscopes.