This award is for a Science and Technology Center devoted to the emerging area of nanobiotechnology that involves a close synthesis of nano-microfabrication and biological systems. The Nanobiotechnology Center (NBTC) features a highly interdisciplinary, close collaboration between life scientists, physical scientists, and engineers from Cornell University, Princeton University, Oregon Health Sciences University, and Wadsworth Center of the New York State Health Department. The integrating vision of the NBTC is that nanobiotechnology will be the genesis of new insights into the function of biological systems, and lead to the design of new classes of nano- and microfabricated devices and systems. Biological systems present a particular challenge in that the diversity of materials and chemical systems for biological applications far exceeds those for silicon-based technology in the integrated-circuit industry. New fabrication processes appropriate for biological materials will require a substantial expansion in knowledge about the interface between organic and inorganic systems. The ability to structure materials and pattern surface chemistry at small dimensions ranging from the molecular to cellular scale are the fundamental technologies on which the research of the NBTC is based. Nanofabrication can also be used to form new analytical probes for interrogating biological systems with unprecedented spatial resolution and sensitivity. Three unifying technology platforms that foster advances in materials, processes, and tools underlie and support the research programs of the NBTC: Molecules of nanobiotechnology; Novel methods of patterning surfaces for attachment of molecules and cells to substrates; and Sensors and devices for nanobiotechnology. Newly developed fabrication capabilities will also be available through the extensive resources of the Cornell Nanofabrication Facility, a site of the NSF National Nanofabrication Users Network. The NBTC will be an integrated part of the educational missions of the participating institutions. NBTC faculty will develop a new cornerstone graduate course in nanobiotechnology featuring nanofabrication with an emphasis on biological applications. Graduate students who enter the NBTC from a background in engineering or biology will cross-train in the other field by engaging in a significant level of complementary course work. Participation in the NBTC will prepare them with the disciplinary depth and cross-disciplinary understanding to become next generation leaders in this emerging field. An undergraduate research experience program with a strong mentoring structure will be established, with emphasis on recruiting women and underrepresented minorities into the program. Educational outreach activities are planned to stimulate the interest of students of all ages. One such activity partnered with the Science center in Ithaca is a traveling exhibition for museum showings on the subject of nano scale size. National and federal laboratories and industrial and other partners will participate in various aspects of the NBTC such as by hosting interns, attendance at symposia and scientist exchanges. Partnering with the industrial affiliates will be emphasized to enhance knowledge transfer and student and postdoctoral training. This specific STC award is managed by the Directorate for Engineering in coordination with the Directorates for Biological Sciences, Mathematical and Physical Sciences, and Education and Human Resources.
This collaborative project aims to establish a national computational resource to move the research community much closer to the realization of the goal of the Tree of Life initiative, namely, to reconstruct the evolutionary history of all organisms. This goal is the computational Grand Challenge of evolutionary biology. Current methods are limited to problems several orders of magnitude smaller, and they fail to provide sufficient accuracy at the high end of their range. The planned resource will be designed as an incubator to promote the development of new ideas for this enormously challenging computational task; it will create a forum for experimentalists, computational biologists, and computer scientists to share data, compare methods, and analyze results, thereby speeding up tool development while also sustaining current biological research projects. The resource will be composed of a large computational platform, a collection of interoperable high-performance software for phylogenetic analysis, and a large database of datasets, both real and simulated, and their analyses; it will be accessible through any Web browser by developers, researchers, and educators. The software, freely available in source form, will be usable on scales varying from laptops to high-performance, Grid-enabled, compute engines such as this project's platform, and will be packaged to be compatible with current popular tools. In order to build this resource, this collaborative project will support research programs in phyloinformatics (databases to store multilevel data with detailed annotations and to support complex, tree-oriented queries), in optimization algorithms, Bayesian inference, and symbolic manipulation for phylogeny reconstruction, and in simulation of branching evolution at the genomic level, all within the context of a virtual collaborative center. Biology, and phylogeny in particular, have been almost completely redefined by modern information technology, both in terms of data acquisition and in terms of analysis. Phylogeneticists have formulated specific models and questions that can now be addressed using recent advances in database technology and optimization algorithms. The time is thus exactly right for a close collaboration of biologists and computer scientists to address the IT issues in phylogenetics, many of which call for novel approaches, due to a combination of combinatorial difficulty and overall scale. The project research team includes computer scientists working in databases, algorithm design, algorithm engineering, and high-performance computing, evolutionary biologists and systematists, bioinformaticians, and biostatisticians, with a history of successful collaboration and a record of fundamental contributions, to provide the required breadth and depth. This project will bring together researchers from many areas and foster new types of collaborations and new styles of research in computational biology; moreover, the interaction of algorithms, databases, modeling, and biology will give new impetus and new directions in each area. It will help create the computational infrastructure that the research community will use over the next decades, as more whole genomes are sequenced and enough data are collected to attempt the inference of the Tree of Life. The project will help evolutionary biologists understand the mechanisms of evolution, the relationships among evolution, structure, and function of biomolecules, and a host of other research problems in biology, eventually leading to major progress in ecology, pharmaceutics, forensics, and security. The project will publicize evolution, genomics, and bioinformatics through informal education programs at museum partners of the collaborating institutions. It also will motivate high-school students and college undergraduates to pursue careers in bioinformatics. The project provides an extraordinary opportunity to train students, both undergraduate and graduate, as well as postdoctoral researchers, in one of the most exciting interdisciplinary areas in science. The collaborating institutions serve a large number of underrepresented groups and are committed to increasing their participation in research.
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TEAM MEMBERS:
Tandy WarnowDavid HillisLauren MeyersDaniel MirankerWarren Hunt, Jr.
The "Salmon Research Team: A Native American Technology, Research and Science Career Exposure Program" is a three-year, youth-based ITEST project submitted by the Oregon Museum of Science and Industry. The project seeks to provide advanced information technology and natural science career exposure and training to 180 middle level and high school students. Mostly first-generation college-bound students, the target audience represents the Native American community and those with Native American affiliations in reservation, rural and urban areas. Students will investigate computer modeling of complex ecological, hydrological and geological problems associated with salmon recovery efforts. Field experiences will be provided in three states: Oregon, Washington and northern California. The participation of elders and tribal researchers will serve as a bridge between advanced scientific technology and traditional ecological knowledge to explore sustainable land management strategies. Students will work closely with Native American and other scientists and resource managers throughout the Northwest who use advanced technologies in salmon recovery efforts. Student participation in IT-dependent science enrichment and research activities involving natural science fields of investigation will occur year round. Middle school students are expected to receive at least 330 contact hours including a one-week summer research experience, a one-week spring break program, and seven weekends of residential programs during the school year. The high school component consists of 460 contact hours reflecting one additional week for the summer research experience. In addition to watershed and salmon recovery related research, students will be involved in other ancillary research projects. A vast array of partners are positioned to support the field research experience including, for example, the U.S. Department of the Interior, Redwood National State Park, College of Natural Resources and Sciences at Humboldt State University, Confederated Tribes of the Warm Springs, University of Oregon Institute of Marine Biology, University of Washington Columbia Basin Research project, the Northwest Center for Sustainable Resources at Chemeketa Community College and the Integrated Natural Resource Technology program at Mt. Hood Community College. The project is intended to serve as a model for IT-based youth science programs that address national and state education standards and are relevant to the cultural experience of Native American students. Two mentors will provide continued support to students: an academic mentor at the student's schools and a professional mentor from a local university or natural resource agency. Incentives will be provided for student participation including stipends and internships. Career exposure and work-related skills are integrated throughout the project activities and every program component. Creative strategies are used to encourage family involvement including, for example, salmon bakes and museum discounts.
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TEAM MEMBERS:
Travis Southworth-NeumeyerDaniel Calvert
Understanding the Science Connected to Technology (USCT) targets information technology (IT) experiences in a comprehensive training program and professional support system for students and teachers in science, technology, engineering and mathematics (STEM). Participants have opportunities to assume leadership roles as citizen volunteers within the context of science and technology in an international watershed basin. Training includes collection, analysis, interpretation and dissemination of scientific data. BROADER IMPACTS: Building on a student volunteer monitoring program called River Watch, the USCT project enables student scientists to conduct surface water quality monitoring activities, analyze data and disseminate results to enhance local decision-making capacity. The project incorporates state and national education standards and has the potential to reach 173 school jurisdictions and 270,000 students. USCT will directly impact 81 teachers, 758 students and 18 citizen volunteers. The USCT project provides direct scientist mentor linkages for each participating school. This linkage provides a lasting process for life-long learning and an understanding of how IT and STEM subject matter is applied by resource professionals. Broader impacts include accredited coursework for teachers and students, specialized training congruent with the "No Child Left Behind Act of 2001," and building partnerships with Native American schools. INTELLECTUAL MERIT: The USCT project is designed to refocus thinking from static content inside a textbook to a process of learning that includes IT and STEM content. The USCT engages students (the next generation of decision makers) in discovery of science and technology and expands education beyond current paradigms and political jurisdictions.
The Fort Worth Museum of Science and History proposes to develop a 5,000 sq ft traveling exhibition, along with educational material and programs. Motivated by the challenge of solving a crime, visitors will become engaged in a scientific investigation that cuts across the multiple disciplines of forensic science. This project builds upon the successful implementation of "Whodunit? The Science of Solving Crime," funded by a prior NSF grant (ESI-9253370). The proposed exhibition will travel to the member institutions of the Science Museum Exhibit Collaborative, where the primary target audiences will be children in the upper elementary and middle school years. The proposed 12-month planning grant would enable research, front-end evaluation, project team meetings, and the development of a conceptual plan and a business plan for the new exhibition beginning. The Museum will develop specific plans to reach underserved audiences and to examine the feasibility of creating a version for small science centers.
The University of California, Berkeley is developing "Windows on Research," a two-year experimental exhibit project at the Lawrence Hall of Science focused on engaging and informing the public about current scientific research. The project will develop and evaluate different media to translate the leading edge of nanotechnology research for the science center audience by featuring live demonstrations and presentations, physical- and technology-based exhibits, and Internet-based exhibits. Formative evaluation of all products, including ongoing public focus groups and surveys, will be used to establish which of the several media, alone or combined, work best to communicate research content. The project team also is developing new assessment tools to test usability and effectiveness of the artificial intelligence and technology-based components in conveying content. The results of this prototype effort to present ongoing research in a museum setting will be disseminated to the informal science education field. The PI, Marco Molinaro, and the team from the Lawrence Hall of Science will work closely with scientists representing research in a number of nanotechnology fields. These scientists bring expertise in the areas of materials science, chemistry, education, bioengineering, mechanical engineering, molecular and cell biology, geochronology and isotope geochemistry, and psychology.
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TEAM MEMBERS:
Marco MolinaroUniversity of California-BerkeleyDarrell Porcello
National Geographic Television requests $1,121,583 (35%) of a total project budget of $3,192,249, to produce a documentary series in 13 half-hour and one hour-long special, "Facing the Wild: The Crittercam Chronicles," with associated informal science education materials and programs. This project will feature the natural histories of some of the Earth's most enigmatic and charismatic marine species, highlight the groundbreaking technology employed to study these extraordinary creatures and celebrate the scientists who devote their lives to understanding marine creatures. The project's goals include: to educate audiences about the vital importance of the world's oceans to the health of the planet; to celebrate the ingenuity of novel technology developed for science and exploration; to illustrate that many tantalizing mysteries remain yet unsolved and a great deal of exciting science and exploration has yet to be done; to provide viewers with scientific role models and help motivate them to pursue careers in science. Employing cutting-edge remote imaging tools, including "crittercam", and National Geographic's trademark storytelling, Facing the Wild's strong conservation message is designed to appeal to a national and global audience. A robust web site, virtual teacher workshops and Student Ocean Conferences will augment the impact of the series.
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TEAM MEMBERS:
Greg MarshallKeenan SmartBarbara Flagg
The Educational Broadcasting Corporation (WNET in New York) is developing and producing a new public television project exploring cutting-edge technology. The project consists of an eight-part hourly broadcast component; six 60-second "mini-programs;" a World Wide Web component; and extensive educational outreach targeted to adults aged 25-39 and older. The topics for the eight programs in season one are: Replacements - prosthetic devices and biologically electronic artificial body parts In Search of Eve - the race to decode the human genome Light of the 21st Century - Fiber Optics Nanotechnology - molecular manipulation of materials Technospy - technologies used to gain information Sports Technology - the pursuit of better equipment and training regimes Artificial Intelligence - efforts to create computers the mimic human intelligence Appropriate Technologies - technologies that use local, inexpensive material Beth Hoppe, WNET's Director of Science Programs will serve as Executive Producer for the series. Each of the programs would be produced by an independent producer selected by WNET. Content advisors include: Angela Christiano, Departments of Dermatology, Genetics and Development, Columbia University; Sheila Sen Jasanoff, Harvard University JFK School of Government; Horace Freeland Judson, Center for History of Recent Science, George Washington University; Michio Kaku, theoretical physicist, CUNY and host, Explorations radio series; Wilfred Pinfold, Microprocessor Research Labs, Intel Corp.; and Barbara Wilson, chief technologist, NASA's Jet Propulsion Laboratory
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TEAM MEMBERS:
Beth HoppeTamara RobinsonWilliam GrantBarbara Flagg
The Science Museum of Minnesota (SMM) will develop "Cyborgs: A Natural History of Machines and Humans." The Project will result in a national traveling exhibit, a web site, and a complement of related educational programs focused on the boundaries between humans and their machines and on recent scientific efforts to understand the human body and mind. The 6,000-square-foot exhibit will open at the SMM before traveling to the six large museums in the Science Museum Exhibit Collaborative (SMEC), and then will be available for lease by other museums.
Over three years, Science Central is producing 624 television segments that will present current, ongoing research through local newscasts on ABC and NBC stations nationwide. In addition to the regular research segments, ScienCentral will produce six "sweeps" series per year focusing on important new fields of research including: nanotechnology, genetics/genomics, ocean science, global climate change and brain sciences. An advisory board of scientists, teachers, science journalists and public information officers help inform the producers about individual stories and evolving fields of research, and they provide access to scientists and field research. They also provide scientific input and check the stories for accuracy. To facilitate production and to assure that research is covered on an international basis, ScienCentral will establish a footage consortium to exchange science news video with major Canadian and European newscasters. They also will provide the news stories to science centers for use in their interactive exhibits and web sites.
National Video Resources, in collaboration with the American Library Association and the History of Science Society, is developing and implementing six-week discussion programs at 100 libraries across the country. The "Research Revolution and the Shaping of Modern Life" discussions will illuminate the organization and goals of scientific-technical work, the critical outcomes of research and development, the material and social byproducts of such work, and the ethical issues that sometimes result. During the program participants will screen and discuss documentary films on topics such as: an introduction to the rise of organized laboratory research and its results; new developments in quantum technologies and nanotechnology; recent developments in materials science and how artificially created materials have defined a modern way of life; the impact of genetic engineering and the Human Genome Project; medical imaging from x-rays to MRIs and CT-scans; and the science of meteorology and the problems of global climate change. Discussions will be lead by local scholars from Universities and research laboratories located near a participating library.
A permanent exhibition entitled "Search for Extraterrestrial Life" will engage visitors at the New York Hall of Science in applying the fundamental biology of life on Earth to understanding the search for life elsewhere. The 4,000 sq. ft. exhibition and accompanying programs will engage visitors in learning more about the wide range of conditions that support life on Earth, and how these life requirements shape the search on Mars and other planetary objects for any existing life forms. In addition, the technologies and strategies that scientists are developing to detect any life elsewhere will be highlighted. It is expected that 500,000 visitors each year will participate with the exhibit and its associated programs. Another dissemination plan for the project will be posting fabrication drawings and scripts in readily accessible formats on the Internet. Copies of all computer interactives on electronic media will be available to science-technology centers, museums and other informal learning institutions.