I have been involved in College education since my days as a student in the Universidad de Buenos Aires. At that time, 1960, I helped to teach the course of Scientific Russian given in the Faculty of Sciences; strange as it might seem, the aim of the course was to allow the students to use scientific books especially in the area of Physics and Mathematics.
This award is for a Science and Technology Center devoted to the emerging area of nanobiotechnology that involves a close synthesis of nano-microfabrication and biological systems. The Nanobiotechnology Center (NBTC) features a highly interdisciplinary, close collaboration between life scientists, physical scientists, and engineers from Cornell University, Princeton University, Oregon Health Sciences University, and Wadsworth Center of the New York State Health Department. The integrating vision of the NBTC is that nanobiotechnology will be the genesis of new insights into the function of biological systems, and lead to the design of new classes of nano- and microfabricated devices and systems. Biological systems present a particular challenge in that the diversity of materials and chemical systems for biological applications far exceeds those for silicon-based technology in the integrated-circuit industry. New fabrication processes appropriate for biological materials will require a substantial expansion in knowledge about the interface between organic and inorganic systems. The ability to structure materials and pattern surface chemistry at small dimensions ranging from the molecular to cellular scale are the fundamental technologies on which the research of the NBTC is based. Nanofabrication can also be used to form new analytical probes for interrogating biological systems with unprecedented spatial resolution and sensitivity. Three unifying technology platforms that foster advances in materials, processes, and tools underlie and support the research programs of the NBTC: Molecules of nanobiotechnology; Novel methods of patterning surfaces for attachment of molecules and cells to substrates; and Sensors and devices for nanobiotechnology. Newly developed fabrication capabilities will also be available through the extensive resources of the Cornell Nanofabrication Facility, a site of the NSF National Nanofabrication Users Network. The NBTC will be an integrated part of the educational missions of the participating institutions. NBTC faculty will develop a new cornerstone graduate course in nanobiotechnology featuring nanofabrication with an emphasis on biological applications. Graduate students who enter the NBTC from a background in engineering or biology will cross-train in the other field by engaging in a significant level of complementary course work. Participation in the NBTC will prepare them with the disciplinary depth and cross-disciplinary understanding to become next generation leaders in this emerging field. An undergraduate research experience program with a strong mentoring structure will be established, with emphasis on recruiting women and underrepresented minorities into the program. Educational outreach activities are planned to stimulate the interest of students of all ages. One such activity partnered with the Science center in Ithaca is a traveling exhibition for museum showings on the subject of nano scale size. National and federal laboratories and industrial and other partners will participate in various aspects of the NBTC such as by hosting interns, attendance at symposia and scientist exchanges. Partnering with the industrial affiliates will be emphasized to enhance knowledge transfer and student and postdoctoral training. This specific STC award is managed by the Directorate for Engineering in coordination with the Directorates for Biological Sciences, Mathematical and Physical Sciences, and Education and Human Resources.
This collaborative project aims to establish a national computational resource to move the research community much closer to the realization of the goal of the Tree of Life initiative, namely, to reconstruct the evolutionary history of all organisms. This goal is the computational Grand Challenge of evolutionary biology. Current methods are limited to problems several orders of magnitude smaller, and they fail to provide sufficient accuracy at the high end of their range. The planned resource will be designed as an incubator to promote the development of new ideas for this enormously challenging computational task; it will create a forum for experimentalists, computational biologists, and computer scientists to share data, compare methods, and analyze results, thereby speeding up tool development while also sustaining current biological research projects. The resource will be composed of a large computational platform, a collection of interoperable high-performance software for phylogenetic analysis, and a large database of datasets, both real and simulated, and their analyses; it will be accessible through any Web browser by developers, researchers, and educators. The software, freely available in source form, will be usable on scales varying from laptops to high-performance, Grid-enabled, compute engines such as this project's platform, and will be packaged to be compatible with current popular tools. In order to build this resource, this collaborative project will support research programs in phyloinformatics (databases to store multilevel data with detailed annotations and to support complex, tree-oriented queries), in optimization algorithms, Bayesian inference, and symbolic manipulation for phylogeny reconstruction, and in simulation of branching evolution at the genomic level, all within the context of a virtual collaborative center. Biology, and phylogeny in particular, have been almost completely redefined by modern information technology, both in terms of data acquisition and in terms of analysis. Phylogeneticists have formulated specific models and questions that can now be addressed using recent advances in database technology and optimization algorithms. The time is thus exactly right for a close collaboration of biologists and computer scientists to address the IT issues in phylogenetics, many of which call for novel approaches, due to a combination of combinatorial difficulty and overall scale. The project research team includes computer scientists working in databases, algorithm design, algorithm engineering, and high-performance computing, evolutionary biologists and systematists, bioinformaticians, and biostatisticians, with a history of successful collaboration and a record of fundamental contributions, to provide the required breadth and depth. This project will bring together researchers from many areas and foster new types of collaborations and new styles of research in computational biology; moreover, the interaction of algorithms, databases, modeling, and biology will give new impetus and new directions in each area. It will help create the computational infrastructure that the research community will use over the next decades, as more whole genomes are sequenced and enough data are collected to attempt the inference of the Tree of Life. The project will help evolutionary biologists understand the mechanisms of evolution, the relationships among evolution, structure, and function of biomolecules, and a host of other research problems in biology, eventually leading to major progress in ecology, pharmaceutics, forensics, and security. The project will publicize evolution, genomics, and bioinformatics through informal education programs at museum partners of the collaborating institutions. It also will motivate high-school students and college undergraduates to pursue careers in bioinformatics. The project provides an extraordinary opportunity to train students, both undergraduate and graduate, as well as postdoctoral researchers, in one of the most exciting interdisciplinary areas in science. The collaborating institutions serve a large number of underrepresented groups and are committed to increasing their participation in research.
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TEAM MEMBERS:
Tandy WarnowDavid HillisLauren MeyersDaniel MirankerWarren Hunt, Jr.
The National Center for Earth-surface Dynamics (NCED) is a Science and Technology Center focused on understanding the processes that shape the Earth's surface, and on communicating that understanding with a broad range of stakeholders. NCED's work will support a larger, community-based effort to develop a suite of quantitative models of the Earth's surface: a Community Sediment Model (CSM). Results of the NCED-CSM collaboration will be used for both short-term prediction of surface response to natural and anthropogenic change and long-term interpretation of how past conditions are recorded in landscapes and sedimentary strata. This will in turn help solve pressing societal problems such as estimation and mitigation of landscape-related risk; responsible management of landscape resources including forests, agricultural, and recreational areas; forecasting landscape response to possible climatic and other changes; and wise development of resources like groundwater and hydrocarbons that are hosted in buried sediments. NCED education and knowledge transfer programs include exhibits and educational programs at the Science Museum of Minnesota, internships and programs for students from tribal colleges and other underrepresented populations, and research opportunities for participants from outside core NCED institutions. The Earth's surface is the dynamic interface among the lithosphere, hydrosphere, biosphere, and atmosphere. It is intimately interwoven with the life that inhabits it. Surface processes span environments ranging from high mountains to the deep ocean and time scales from fractions of a second to millions of years. Because of this range in forms, processes, and scales, the study of surface dynamics has involved many disciplines and approaches. A major goal of NCED is to foster the development of a unified, quantitative science of Earth-surface dynamics that combines efforts in geomorphology, civil engineering, biology, sedimentary geology, oceanography, and geophysics. Our research program has four major themes: (1) landscape evolution, (2) basin evolution, (3) biological sediment dynamics, and (4) integration of morphodynamic processes across environments and scales. Each theme area provides opportunities for exchange of information and ideas with a wide range of stakeholders, including teachers and learners at all levels; researchers, managers, and policy makers in both the commercial and public sectors; and the general public.
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Efi Foufoula-GeorgiouChristopher PaolaGary Parker
The importance of reporting current science to the general public is more important now than ever before. The best way to ensure enthusiastic support for science is to engage the general public as directly as possible. Unlike schooling, learning in a museum is self-motivated, self-directed, and can be lifelong. The partnership between Columbia University's MRSEC (Materials Research Science and Engineering Center) and the New York Hall of Science will do this in an exciting manner by development of innovative 'rolling exhibits' (Discovery Carts) that are visually attractive, intellectually stimulating and demonstrate current research. This project will unite a dynamic University research faculty, dedicated graduate students, and high school teachers from one of the largest and best known teacher research experience programs in the country. NY Hall of Science, specialists in public science education, have developed exhibitions, over the past 20 years, for school and family group visitors in biology, chemistry and physics. Most recently, the Hall opened an 800-foot biochemistry discovery lab featuring ten experiments that teach visitors about the role of molecules in everyday life. The lab is facilitated by an explainer, and hundreds of families use the lab throughout the year. All exhibits and programs have rigorous science presented in an engaging manner in an educationally non-threatening environment. Columbia University is one of the premier research institutions in the country. Columbia's MRSEC is engaged in multi-faceted educational outreach activities in the New York metropolitan area, including a close working relationship with Columbia's 16 year old RET program. Together these institutions are well situated to involve the research community in public education activities that will inform the public about the current advances in science. Teachers and graduate students who have worked in MRSEC labs will assist in bringing new skills and ideas to the development of museum programming and exhibits. The teachers have experienced both the research projects first-hand and have had the experience in translating the research into meaningful classroom activities for their students. The graduate students have worked alongside the teachers, assisting them in making the research meaningful to high school students. Broader Impact: Highly skilled educators who can improve a young person's chances for success are like gold for the nation's schools, which are under pressure for tough accountability standards. Teachers will influence over a thousand students during the course of their careers. The Hall's Explainers are of high school and college age. These two groups will have positive impacts on our society for years to come. They will benefit from participation, and the tens of thousands of visitors to the museum will learn about cutting edge research.
Genetics was developed by The Tech staff in collaboration with Stanford University and was funded by the National Institutes of Health Science Education Partnership Award (SEPA) program. The evaluation documents the impact and effectiveness of the exhibition using timing and tracking observations and exit interviews. It also examines the partnership between The Tech and Stanford University through interviews with graduate students, who conduct programs in the exhibition, and their supervisor (results are not included in this summary).
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Randi KornThe Tech Museum of Innovation
The Self-Reliance Foundation (SRF) Conociendo Tu Cuerpo (Know Your Body) Hispanic Community Health Sciences Education project is an initiative designed to introduce Hispanic students and families to biomedical science and health education resources, and increase their participation levels in these fields. The educational goals of the project are to: (1) Encourage Hispanic undergraduate students to pursue careers in biomedicine and science through a mentoring program at the university level; (2) Inspire an interest in biomedical science among Hispanic elementary-age students and parents through community outreach activities; (3) Inform Hispanic parents about biomedical science education standards and academic requirements for pursuing biomedical and science related careers; and (4) Inform and inspire Hispanic students and their families about the biomedical sciences and related careers through a series of daily nationally broadcast Spanish-language radio capsules, and a nationally syndicated Spanish newspaper column. Conociendo Tu Cuerpo (Know Your Body) includes several key components: A model, Washington, D.C., area coalition of informal science, health, community, education, and media organizations that will publicize and provide hands-on health science activities at community festivals and other community settings; Hispanic undergraduate student health-science fellows to be trained and provided experience in facilitating health science activities; and nationally broadcast Spanish-language radio capsules that will cover topics in areas of biomedicine, research, education, and health-science careers. Parents and students will be able to access additional information about biomedical science opportunities and Hispanic role models in the biomedical sciences through the project's Conociendo Tu Cuerpo website and the bilingual 800 telephone help line promoted by 147 participating radio stations and 102 newspapers nationwide. The project will be supported at the national level through collaboration with the Hispanic Radio Network and the Pacific Science Center. The Washington, D.C., collaborative will include the Capital Children's Museum, local Spanish language radio stations, area universities, and health and community organizations. Development Associates, the largest American education and evaluation consulting corporation, will evaluate the project.
The long-term goal of this project is to expand and disseminate our innovative internship and near-peer mentoring models for minority youth and women in the biomedical sciences, thus increasing the number of minority students participating in the quantitative disciplines. Dissemination and expansion of the program will take place in three steps: (1) Within the national capital region through the Internet and cooperative arrangements with established educational initiatives within DCPS system; (2) For year 2, expand to one site outside the national capital area. The site would be for a group that had already begun to model its fledgling program on our STARS program, or one of the specific sites discussed in Aim 3. The likely site would be at Fort Monmouth, N.J., since Dr. Constella Zimmerman is planning to start a STARS initiative; and (3) Extend the program to specific sites within selected cities, and utilize current contacts in states that do not yet have a SEPA program to disseminate.
The Miami Museum of Science, in collaboration with University of Miami's (UM) School of Medicine, is requesting a Phase II grant to support national replication of the Biomedical Training, Research and College Prep (BioTrac) Project. The goal of Phase I, now in its final year of funding, was to develop a replicable model aimed at increasing the numbers of underserved students entering the biomedical research pipeline. Phase I focused on priority areas under Healthy People 2000 reflecting health issues of interest to the community as well as resources available through UM's Jackson Memorial Medical Center. Comprising hands-on project-based programming, career awareness activities, college prep, research internships and college residential experiences, the project has served 98 students to date, of whom 88% are low-income and 96% reside in homes where English is the second language. Of the 43 seniors who have graduated to date, 42 are enrolled in post-secondary studies. Of these, 52% have chosen a science-related major, and of these, 73% have chosen a biomedical course of study. Under the proposed Phase II project, the useum will establish BioTrac as a national demonstration site, extending BioTrac strategies and materials to formal and informal science institutions (ISis) through site-based institutes, distance-learning opportunities and professional conferences and publications. Continued delivery of BioTrac programming at the demonstration site will also further increase the number of underrepresented students entering the biomedical research pipeline, and allow for further programming aimed at increasing public understanding of Healthy People 2010 priorities and biomedical research. The museum will target ISis with youth programs to attend a three-day replication institute, reaching a minimum of 30 ISis during the grant. Through participation in national conferences and professional development sponsored by the Association of Science-Technology Centers, representng 340 ISis, the model has the capacity to impact small, medium, and large science centers nationwide. The model will also be adaptable for use by the other 123 Upward Bound Math & Science Centers engaged in science enrichment programming for underserved youth. Finally, elements of the model will be suitable for extracurricular school-based science clubs and high school magnet programs focused on biomedicine, further extending the potential impact of the model to school districts nationwide.