This Integrative Graduate Education and Research Training (IGERT) award supports the establishment of an interdisciplinary graduate training program in Cognitive, Computational, and Systems Neuroscience at Washington University in Saint Louis. Understanding how the brain works under normal circumstances and how it fails are among the most important problems in science. The purpose of this program is to train a new generation of systems-level neuroscientists who will combine experimental and computational approaches from the fields of psychology, neurobiology, and engineering to study brain function in unique ways. Students will participate in a five-course core curriculum that provides a broad base of knowledge in each of the core disciplines, and culminates in a pair of highly integrative and interactive courses that emphasize critical thinking and analysis skills, as well as practical skills for developing interdisciplinary research projects. This program also includes workshops aimed at developing the personal and professional skills that students need to become successful independent investigators and educators, as well as outreach programs aimed at communicating the goals and promise of integrative neuroscience to the general public. This training program will be tightly coupled to a new research focus involving neuro-imaging in nonhuman primates. By building upon existing strengths at Washington University, this research and training initiative will provide critical new insights into how the non-invasive measurements of brain function that are available in humans (e.g. from functional MRI) are related to the underlying activity patterns in neuronal circuits of the brain. IGERT is an NSF-wide program intended to meet the challenges of educating U.S. Ph.D. scientists and engineers with the interdisciplinary background, deep knowledge in a chosen discipline, and the technical, professional, and personal skills needed for the career demands of the future. The program is intended to catalyze a cultural change in graduate education by establishing innovative new models for graduate education and training in a fertile environment for collaborative research that transcends traditional disciplinary boundaries.
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TEAM MEMBERS:
Kurt ThoroughmanGregory DeAngelisRandy BucknerSteven PetersenDora Angelaki
Science Club is an after school program created in partnership between Northwestern University and the Boys & Girls Clubs of Chicago. Every week throughout the academic year, middle school youth (grades 5-8) work in small groups with their graduate student mentors on challenging, hands-on experiments. The six Science Club curricular modules cover topics ranging from biomedical engineering to food science, all with the goals of helping youth to 1) improve their understanding of the scientific method, 2) develop scientific habits of mind, and 3) increase their interest in STEM fields, particularly health-related careers. Science Club serves 60 youth every quarter with the help of 30 trained scientist mentors. Science Club meets three days a week at the Pedersen-McCormick Boys & Girls Club in Chicago, IL.
This award continues funding of a Center to conduct research and education on the interactions of nanomaterials with living systems and with the abiotic environment. The goals of this Center are to develop a predictive understanding of biological and ecological toxicology for nanomaterials, and of their transport and transformation in the environment. This Center engages a highly interdisciplinary, multi-institutional team in an integrated research program to determine how the physical and chemical properties of nanomaterials determine their environmental impacts from the cellular scale to that of entire ecosystems. The research approach promises to be transformative to the science of ecotoxicology by combining high throughput screening assays with computational and physiological modeling to predict impacts at higher levels of biological organization. The Center will unite the fields of engineering, chemistry, physics, materials science, cell biology, ecology, toxicology, computer modeling, and risk assessment to establish the foundations of a new scientific discipline: environmental nanotoxicology. Research on nanomaterials and development of nanotechnology is expanding rapidly and producing discoveries that promise to benefit the nation?s economy, and improve our ability to live sustainably on earth. There is now a critical need to reduce uncertainty about the possible negative consequences of nanomaterials in the environment, while at the same time providing guidelines for their safe design to prevent environmental and toxicological hazards. This Center addresses this societal need by developing a scientific framework of risk prediction that is paradigm-shifting in its potential to keep pace with the commercial expansion of nanotechnology. Another impact of the Center will be development of human resources for the academic community, industry and government by training the next generation of nano-scale scientists, engineers, and regulators to anticipate and mitigate potential future environmental hazards of nanotechnology. Partnerships with other centers will act as powerful portals for the dissemination and integration of research findings to the scientific, educational, and industrial communities, both nationally and internationally. This Center will contribute to a network of nanotechnology centers that serve the national needs and expand representation and access to this research and knowledge network through programs directed at California colleges serving underrepresented groups. Outreach activities, including a journalist-scientist communication program, will serve to inform both experts and the public at large about the safety issues surrounding nanotechnology and how to safely produce, use, and dispose of nanomaterials.
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TEAM MEMBERS:
Andre NelYoram CohenHilary GodwinArturo KellerPatricia Holden
This project will introduce students ages 8-14, including underserved students; their teachers and families; and the general public to three biomedical research areas inspired by NIH's Roadmap for Medical Research: biological pathways, bioinformatics and nanomedicine. These areas are unfamiliar to many adults and are not introduced in science curricula. Using the metaphor of a hardware store (i.e., building materials, tools, parts, home repair projects), the project will introduce families, students and teachers to three ideas: (1) The body maintains and repairs itself at the molecular, cell, tissue, organ and system levels; (2) Biomedical researchers are uncovering new complexities at the molecular level that can increase our understanding of how the body works; and (3) Developments in nanomedicine can lead to discoveries and treatments. In a hardware store theater and workshop space and in a virtual hardware store, the project will develop and present demonstrations and basic- and intermediate-level labs (for 2nd- and 6th-grade students or families); train museum staff and interns to present the programs; offer orientation workshops to teachers from Title I schools; develop a teacher's guide; conduct outreach in middle schools; engage scientists to talk about their work and help them communicate with the public; and create a manual of materials and activities for other science centers. The evaluation plan will include formative research on activities and assessment of how well repair metaphors facilitate understanding of clinical issues. A team of scientists, museum staff, science teachers, and biology and medical students will guide the development of education components.
Our Center works with students from kindergarten through graduate school and beyond. We work with teachers and scientists and combine our knowledge to inspire students to pursue careers in neural engineering and neuroscience. Program activities include summer research programs, curriculum development, school visits, teacher/student workshops, science festivals, and international student exchanges.
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TEAM MEMBERS:
University of WashingtonEric Chudler