This collaborative project aims to establish a national computational resource to move the research community much closer to the realization of the goal of the Tree of Life initiative, namely, to reconstruct the evolutionary history of all organisms. This goal is the computational Grand Challenge of evolutionary biology. Current methods are limited to problems several orders of magnitude smaller, and they fail to provide sufficient accuracy at the high end of their range. The planned resource will be designed as an incubator to promote the development of new ideas for this enormously challenging computational task; it will create a forum for experimentalists, computational biologists, and computer scientists to share data, compare methods, and analyze results, thereby speeding up tool development while also sustaining current biological research projects. The resource will be composed of a large computational platform, a collection of interoperable high-performance software for phylogenetic analysis, and a large database of datasets, both real and simulated, and their analyses; it will be accessible through any Web browser by developers, researchers, and educators. The software, freely available in source form, will be usable on scales varying from laptops to high-performance, Grid-enabled, compute engines such as this project's platform, and will be packaged to be compatible with current popular tools. In order to build this resource, this collaborative project will support research programs in phyloinformatics (databases to store multilevel data with detailed annotations and to support complex, tree-oriented queries), in optimization algorithms, Bayesian inference, and symbolic manipulation for phylogeny reconstruction, and in simulation of branching evolution at the genomic level, all within the context of a virtual collaborative center. Biology, and phylogeny in particular, have been almost completely redefined by modern information technology, both in terms of data acquisition and in terms of analysis. Phylogeneticists have formulated specific models and questions that can now be addressed using recent advances in database technology and optimization algorithms. The time is thus exactly right for a close collaboration of biologists and computer scientists to address the IT issues in phylogenetics, many of which call for novel approaches, due to a combination of combinatorial difficulty and overall scale. The project research team includes computer scientists working in databases, algorithm design, algorithm engineering, and high-performance computing, evolutionary biologists and systematists, bioinformaticians, and biostatisticians, with a history of successful collaboration and a record of fundamental contributions, to provide the required breadth and depth. This project will bring together researchers from many areas and foster new types of collaborations and new styles of research in computational biology; moreover, the interaction of algorithms, databases, modeling, and biology will give new impetus and new directions in each area. It will help create the computational infrastructure that the research community will use over the next decades, as more whole genomes are sequenced and enough data are collected to attempt the inference of the Tree of Life. The project will help evolutionary biologists understand the mechanisms of evolution, the relationships among evolution, structure, and function of biomolecules, and a host of other research problems in biology, eventually leading to major progress in ecology, pharmaceutics, forensics, and security. The project will publicize evolution, genomics, and bioinformatics through informal education programs at museum partners of the collaborating institutions. It also will motivate high-school students and college undergraduates to pursue careers in bioinformatics. The project provides an extraordinary opportunity to train students, both undergraduate and graduate, as well as postdoctoral researchers, in one of the most exciting interdisciplinary areas in science. The collaborating institutions serve a large number of underrepresented groups and are committed to increasing their participation in research.
DATE:
-
TEAM MEMBERS:
Tandy WarnowDavid HillisLauren MeyersDaniel MirankerWarren Hunt, Jr.
resourceprojectProfessional Development, Conferences, and Networks
The Nanoscale Science and Engineering Education (NSEE) Center for Learning and Teaching (NCLT) would focus on the research and development of nano-science instructional resources for grades 7-16, related professional development opportunities for 7-12 teachers, and programs infused with nano-science content for education doctoral students. The Center would bring together educators and scientists from several areas of nano-science and engineering research to collaborate with science teachers and doctoral candidates in education on both the development of the resources and research on their efficacy. The PI has prior experience as director of the Materials World Modules project, an NSF-funded curriculum currently in use in several secondary schools across the country. Lead partners in the proposed Center are Northwestern University, Purdue University, University of Michigan, University of Illinois at Chicago and University of Illinois at Urbana-Champaign. Additional partners include Argonne National Laboratory, West Point Military Academy, Alabama A & M University, Fisk University, Hampton University, Morehouse College and University of Texas at El Paso. The additional partners will widen the geographic range of the project, expanding opportunities to reach a diverse and currently underrepresented population of graduate students, teachers and ultimately students. STEM and Education faculty and researchers from the partner institutions would participate in interdisciplinary teams to address the Center's mission: Provide national education leadership and resources for advancing NSEE Create and implement professional development programs in NSEE Use innovative ideas in learning to design instructional materials for grades 7-16 Conduct research relating to integration of NSEE into science, technology, engineering and mathematics (STEM) education.
DATE:
-
TEAM MEMBERS:
R. P. H. ChangThomas MasonNcholas GiordanoJoseph Krajcik
Community Ambassadors in Science Exploration (CASE) is a new model for encouraging the appreciation and understanding of science among underserved families through: a corps of teen and adult peer presenters; a curriculum of hands-on learning experiences for families of diverse ages and backgrounds; a regional network of museum-community collaboration; integration of community and museum resources through joint programming; and a longitudinal research study of program impacts. CASE will serve over 20,000 people over three years with peer-presented family learning opportunities and museum experiences. In addition, CASE will train a total of 108 science ambassadors who will offer science workshops at community-based organizations in the languages spoken by their constituencies. Through CASE, the ambassadors will gain training and experience in informal science education that can open the door to possible future career opportunities in community and museum settings. Building on a ten-year history of museum-community collaboration, CASE will be conducted by PISEC, the Philadelphia/Camden Informal Science Education Collaborative. PISEC includes four major Philadelphia informal science institutions: The Franklin Institute, the Philadelphia Zoo, The Academy of Natural Sciences and The New Jersey State Aquarium. This organization conducts research and outreach projects in support of family science learning.
DATE:
-
TEAM MEMBERS:
Minda BorunKathleen WagnerAngela WengnerNaomi Echental
The Science Museum of Minnesota would like to create a network of partnerships between the museum and small community-based science organizations (CBSOs). CBSOs will receive professional development workshops to increase their capacity to produce high quality exhibits and publications and offer effective science programming. A team from each science organization will participate in a 12-hour skills development workshop to cover such topics as exhibit development, audience research, science communication and program development. A workshop "tool kit" will capture the essence of the training workshops and be made available to other museums. Each team will develop a small traveling exhibit and supporting materials. Annual Science Summit programs will showcase the CBSOs to the general public, museum visitors and students, while a CBSO Roundtable will invite the participants to explore collaborations and programming strategies. An online database will be created and a complimentary printed resource guide of all local CBSOs will be available to the public. The model will be tested at two small science centers, the Kirby Science Discovery Center in Sioux Falls, SD, and at the Headwaters Science Center in Bemidji, MN. It is anticipated that 72 organizations and 450 CBSO staff members will be served by this project, in addition to over 5,000 members of the general public.
The MIT Media Laboratory, in collaboration with six museums, will develop the "Playful Invention and Exploration (PIE) Network," with the goal of engaging a broader audience in science inquiry and engineering by enabling more people to create, invent and explore with new digital technologies. PIE museums will integrate the latest MIT technologies and educational research into their ongoing public programs. The museums will organize MindFest events, modeled after a two-day event at MIT in 1999, at which youth, educators, artists, engineers, hobbyists and researchers came together to collaborate on invention projects. The PIE Network will disseminate PIE ideas and activities to educators and families nationally.
DATE:
-
TEAM MEMBERS:
Mitchel ResnickNatalie RuskBakhtiar MikhakMike PetrichKaren Wilkinson