This award is for a Science and Technology Center devoted to the emerging area of nanobiotechnology that involves a close synthesis of nano-microfabrication and biological systems. The Nanobiotechnology Center (NBTC) features a highly interdisciplinary, close collaboration between life scientists, physical scientists, and engineers from Cornell University, Princeton University, Oregon Health Sciences University, and Wadsworth Center of the New York State Health Department. The integrating vision of the NBTC is that nanobiotechnology will be the genesis of new insights into the function of biological systems, and lead to the design of new classes of nano- and microfabricated devices and systems. Biological systems present a particular challenge in that the diversity of materials and chemical systems for biological applications far exceeds those for silicon-based technology in the integrated-circuit industry. New fabrication processes appropriate for biological materials will require a substantial expansion in knowledge about the interface between organic and inorganic systems. The ability to structure materials and pattern surface chemistry at small dimensions ranging from the molecular to cellular scale are the fundamental technologies on which the research of the NBTC is based. Nanofabrication can also be used to form new analytical probes for interrogating biological systems with unprecedented spatial resolution and sensitivity. Three unifying technology platforms that foster advances in materials, processes, and tools underlie and support the research programs of the NBTC: Molecules of nanobiotechnology; Novel methods of patterning surfaces for attachment of molecules and cells to substrates; and Sensors and devices for nanobiotechnology. Newly developed fabrication capabilities will also be available through the extensive resources of the Cornell Nanofabrication Facility, a site of the NSF National Nanofabrication Users Network. The NBTC will be an integrated part of the educational missions of the participating institutions. NBTC faculty will develop a new cornerstone graduate course in nanobiotechnology featuring nanofabrication with an emphasis on biological applications. Graduate students who enter the NBTC from a background in engineering or biology will cross-train in the other field by engaging in a significant level of complementary course work. Participation in the NBTC will prepare them with the disciplinary depth and cross-disciplinary understanding to become next generation leaders in this emerging field. An undergraduate research experience program with a strong mentoring structure will be established, with emphasis on recruiting women and underrepresented minorities into the program. Educational outreach activities are planned to stimulate the interest of students of all ages. One such activity partnered with the Science center in Ithaca is a traveling exhibition for museum showings on the subject of nano scale size. National and federal laboratories and industrial and other partners will participate in various aspects of the NBTC such as by hosting interns, attendance at symposia and scientist exchanges. Partnering with the industrial affiliates will be emphasized to enhance knowledge transfer and student and postdoctoral training. This specific STC award is managed by the Directorate for Engineering in coordination with the Directorates for Biological Sciences, Mathematical and Physical Sciences, and Education and Human Resources.
This collaborative project aims to establish a national computational resource to move the research community much closer to the realization of the goal of the Tree of Life initiative, namely, to reconstruct the evolutionary history of all organisms. This goal is the computational Grand Challenge of evolutionary biology. Current methods are limited to problems several orders of magnitude smaller, and they fail to provide sufficient accuracy at the high end of their range. The planned resource will be designed as an incubator to promote the development of new ideas for this enormously challenging computational task; it will create a forum for experimentalists, computational biologists, and computer scientists to share data, compare methods, and analyze results, thereby speeding up tool development while also sustaining current biological research projects. The resource will be composed of a large computational platform, a collection of interoperable high-performance software for phylogenetic analysis, and a large database of datasets, both real and simulated, and their analyses; it will be accessible through any Web browser by developers, researchers, and educators. The software, freely available in source form, will be usable on scales varying from laptops to high-performance, Grid-enabled, compute engines such as this project's platform, and will be packaged to be compatible with current popular tools. In order to build this resource, this collaborative project will support research programs in phyloinformatics (databases to store multilevel data with detailed annotations and to support complex, tree-oriented queries), in optimization algorithms, Bayesian inference, and symbolic manipulation for phylogeny reconstruction, and in simulation of branching evolution at the genomic level, all within the context of a virtual collaborative center. Biology, and phylogeny in particular, have been almost completely redefined by modern information technology, both in terms of data acquisition and in terms of analysis. Phylogeneticists have formulated specific models and questions that can now be addressed using recent advances in database technology and optimization algorithms. The time is thus exactly right for a close collaboration of biologists and computer scientists to address the IT issues in phylogenetics, many of which call for novel approaches, due to a combination of combinatorial difficulty and overall scale. The project research team includes computer scientists working in databases, algorithm design, algorithm engineering, and high-performance computing, evolutionary biologists and systematists, bioinformaticians, and biostatisticians, with a history of successful collaboration and a record of fundamental contributions, to provide the required breadth and depth. This project will bring together researchers from many areas and foster new types of collaborations and new styles of research in computational biology; moreover, the interaction of algorithms, databases, modeling, and biology will give new impetus and new directions in each area. It will help create the computational infrastructure that the research community will use over the next decades, as more whole genomes are sequenced and enough data are collected to attempt the inference of the Tree of Life. The project will help evolutionary biologists understand the mechanisms of evolution, the relationships among evolution, structure, and function of biomolecules, and a host of other research problems in biology, eventually leading to major progress in ecology, pharmaceutics, forensics, and security. The project will publicize evolution, genomics, and bioinformatics through informal education programs at museum partners of the collaborating institutions. It also will motivate high-school students and college undergraduates to pursue careers in bioinformatics. The project provides an extraordinary opportunity to train students, both undergraduate and graduate, as well as postdoctoral researchers, in one of the most exciting interdisciplinary areas in science. The collaborating institutions serve a large number of underrepresented groups and are committed to increasing their participation in research.
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TEAM MEMBERS:
Tandy WarnowDavid HillisLauren MeyersDaniel MirankerWarren Hunt, Jr.
The National Center for Earth-surface Dynamics (NCED) is a Science and Technology Center focused on understanding the processes that shape the Earth's surface, and on communicating that understanding with a broad range of stakeholders. NCED's work will support a larger, community-based effort to develop a suite of quantitative models of the Earth's surface: a Community Sediment Model (CSM). Results of the NCED-CSM collaboration will be used for both short-term prediction of surface response to natural and anthropogenic change and long-term interpretation of how past conditions are recorded in landscapes and sedimentary strata. This will in turn help solve pressing societal problems such as estimation and mitigation of landscape-related risk; responsible management of landscape resources including forests, agricultural, and recreational areas; forecasting landscape response to possible climatic and other changes; and wise development of resources like groundwater and hydrocarbons that are hosted in buried sediments. NCED education and knowledge transfer programs include exhibits and educational programs at the Science Museum of Minnesota, internships and programs for students from tribal colleges and other underrepresented populations, and research opportunities for participants from outside core NCED institutions. The Earth's surface is the dynamic interface among the lithosphere, hydrosphere, biosphere, and atmosphere. It is intimately interwoven with the life that inhabits it. Surface processes span environments ranging from high mountains to the deep ocean and time scales from fractions of a second to millions of years. Because of this range in forms, processes, and scales, the study of surface dynamics has involved many disciplines and approaches. A major goal of NCED is to foster the development of a unified, quantitative science of Earth-surface dynamics that combines efforts in geomorphology, civil engineering, biology, sedimentary geology, oceanography, and geophysics. Our research program has four major themes: (1) landscape evolution, (2) basin evolution, (3) biological sediment dynamics, and (4) integration of morphodynamic processes across environments and scales. Each theme area provides opportunities for exchange of information and ideas with a wide range of stakeholders, including teachers and learners at all levels; researchers, managers, and policy makers in both the commercial and public sectors; and the general public.
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TEAM MEMBERS:
Efi Foufoula-GeorgiouChristopher PaolaGary Parker
Assessing the Impact of a Visit to a Zoo or Aquarium: A Multi-institutional Research Project will create a functional taxonomy of zoo/aquarium visitors' entering knowledge, attitudes and behaviors. This taxonomy, in conjunction with data about the specific experiences visitors have during their visit, will enable investigators to understand and predict the contribution of zoos and aquariums to the public understanding of animals and their conservation. The results will clarify the role of zoos and aquariums as centers of informal learning and point to ways to strengthen their educational impact. The AZA convened a national advisory committee that commissioned and completed a thorough review, confirming a critical need to conduct more research, particularly research that attempts to ask broad questions, collect data systematically, and includes sufficient number and types of institutions to permit community-wide generalizations. Twelve AZA institutions of various sizes, geographic regions and types will participate in the study. The net result of the study will be a descriptive model of zoo and aquarium visitor learning experiences and development of a set of diagnostic tools to help zoo and aquaria staff understand and enhance the nature and extent of their public impact.
SoundVision Productions is developing and distributing a series of ten, hour-long public radio documentaries that will explore the turbulent boundary between science and the humanities, capturing the present moment of tremendous scientific and scholarly ferment with the unique and intimate power of radio. By introducing the radio audience to the thoughts and voices of some of the world\'s most accomplished scientists, in conversations with the counterparts in the humanities, the series will look at recent developments in science including physics, molecular and cell biology, environmental science, cognitive psychology and neuroscience, and the multiple disciplines of the life sciences reflecting the increasingly subtle and widespread application of evolutionary theory. In each program, a careful account of new scientific ideas and discoveries will be placed within the context of historical and contemporary thought about the human and natural worlds. Barinetta Scott, the Executive Producer, has most recently been the Executive Producer for the highly regarded NSF funded NPR series, "The DNA Files." In developing this project, she will work closely with an advisory committee that includes: John Avise, Research Professor, Dept. of Genetics, University of Georgia Samuel Barondes, Professor and Director of the University of California San Francisco\'s Center for Neurobiology and Psychiatry Terrence Deacon, Associate Professor of Anthropology, Boston University Anne Foerst, Professor of Computer Science and Theology, St. Bonaventure University Ursula Goodenough, Dept. of Biology, Washington University, St. Louis William Irons, Professor of Anthropology, Northwestern University Gordon Kane, Professor of Physics, University of Michigan Jim Miller, Senior Program Associate for the AAAS Program of Dialogue Between Science and Religion W. Mark Richardson, Episcopal Priest, Associate Professor of Systematic Theology, General Theological Seminary Holmes Rolston, University Distinguished Professor in the Department of Philosophy, Colorado State University Michael Ruse, Professor of the Philosophy of Biology and Ethics, at Florida State University Mary Evelyn Tucker, Professor of Religion at Bucknell University Dorothy Wertz, Senior Scientist; Social Science, Ethics, and the Law; The Shriver Center.
Flip It, Fold It, Figure It Out! is a 1500-sq. foot traveling mathematics exhibition with companion take-home educational materials. There are two copies of the traveling exhibit: one for the members of the North Carolina Grassroots Science Museums Collaborative reaching over 500,000 visitors, and a second for travel nationally to science centers reaching an estimated 750,000 additional visitors. Take-home activity kits were developed for visitors to continue informal mathematics explorations at home. The activities included expand and extend the exhibit themes, offering multiple levels to meet the needs of K-5 students and their families.
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TEAM MEMBERS:
Deborah May
resourceprojectProfessional Development, Conferences, and Networks
The Center for Informal Learning and Schools (CILS) is a five-year collaborative effort between the Exploratorium in San Francisco, the University of California at Santa Cruz, and King's College London. The purpose of the Center is to study the intersection of informal science learning that takes place in museums and science centers and formal learning that takes place in schools, and to prepare leaders in informal science education. Through the efforts of the center, new doctoral level leaders will be prepared who understand how informal science learning takes place and how informal institutions can contribute to science education reform. A Ph.D. program will be offered to 16 individuals at King's College London (two cohorts of eight) and a post-doctoral program to six scientists interested in issues of learning and teaching in informal settings. A doctoral program is planned at the University of California at Santa Cruz for 24 students, 12 whose interests are primarily in education and 12 who come from the sciences. In addition to doctoral level training, there will be a certification program for existing informal science professionals to better enable them to support teachers, students and the general public. That program will provide 160 informal science educators 120 hours of professional development experiences, and an additional 24 informal science educators with a master's degree in informal science education at UC Santa Cruz. A Bay Area Institute will be developed to serve as a central focus for all CILS activities. It will bring together researchers and practitioners; it will offer courses and workshops for graduate students; and it will provide a central location for reporting research findings and methodologies that focus on how informal learning institutions can best contribute to science education reform.
Kikim Media requests $743,316 to produce four half-hour television documentaries and associated outreach programs based on Michael Pollan's best-selling book, The Botany of Desire. The project explores the reciprocal nature of people's relationship with plants. The programs focus on the connections between apples and the human desire for sweetness; tulips and the desire for beauty; marijuana and the desire for intoxication; and corn and our desire for control over nature. The project will increase public understanding of diverse subjects including genetics, evolution, cognition and biochemistry as well as biodiversity, genetic diversity and the consequences of their loss. The project will have a broad impact through a national primetime PBS broadcast, an outreach program targeting adult audiences, and an educational module delivering appropriate content (excluding intoxication) to middle and high school audiences. Knight-Williams Research Communications will conduct the evaluation for The Botany of Desire television broadcast and outreach efforts.
Community Science Workshops: Beginning a National Movement is an extension of a successful, NSF-funded project that created a network of community science centers in California. The San Francisco State University will now take this successful venture to a national level by working with the American Association for the Advancement of Science (AAAS) and Quality Education for Minorities (QEM) to establish a new Community Science Workshop (CSW) 8-10 in underserved communities over the next four years. Once sites are selected, CSW directors participate in an intensive two-week training program. This is followed by visits by site mentors, and ongoing support through the WWW and other media, which contributes to the establishment and eventual sustainability of the centers. Each site partners with larger, established museums and science centers locally to gain much needed assistance with exhibits and education programs. Community Science Workshops contain permanent exhibit space, a workshop area for student projects and classroom/storage space. They serve a variety of audiences through after school, family, school and summer science programs. Potential locations include Arizona, Florida, Louisiana, Michigan, Montana, Nebraska, New York, Tennessee, Texas, Washington and the District of Columbia.
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TEAM MEMBERS:
Paul FonteynDaniel Sudran
resourceprojectProfessional Development, Conferences, and Networks
This CAREER grant interweaves research and teaching focused on understanding how social groups construct meaning during scientific conversations across different learning contexts, such as classrooms, museums and the home. This work will be translated into formal educational settings and used to inform teaching practices within pre-service University and in-service school district settings. The research and educational emphasis will be on creating conceptual links between social learning in diverse settings and the creation of corridors of opportunity between formal and informal learning institutions. To date there has been little research with families from cultural and linguistic minority populations, such as Latino families, at informal learning settings and virtually none that integrates formal and informal learning, or impacts teaching. The five-year project will: 1. Conduct Study 1, aimed at making fundamental cross-cultural comparisons of family conversational meaning making at the Monterey Bay Aquarium and linking this work with family interviews, reflective conversations and visits to family homes; 2. Review the theoretical framework and conduct Study 2, which will incorporate lessons learned from Study 1, and linking this research to formal classrooms; and 3. Use the findings (at each stage) to inform teaching practice with UCSC undergraduate (Science majors) and graduate (Science credential, MA and Ph.D.) students, and, in collaboration with teacher research groups for new and experienced teacher in schools that serve predominantly Latino students. This research plan provides an opportunity for viewing several inter-connected mechanisms, including family interactions and conversations, compelling science content, naturalistic learning in museum settings, and, finally, analyzing these factors in order to inform teaching practices that promote bilingual minority students to the rank of scientists.
The Exploratorium will create the "Outdoor Exploratorium," a 10,000-square-foot, open-air exhibit environment comprising 20 to 25 original installations. Each exhibit will allow visitors to interact directly with a variety of elements, that is water, wind, sound, light, and living things, as they exist in the natural world. One of the key components of this project will be the use of "Noticing Tours." Led by staff scientists, artists, educators, exhibit developers, and other "expert noticers," the tours will initiate a dialogue with the visitors as a starting point for exhibit development. To augment visitor learning and unify the museum's entire collection, exhibit text will relate the "Outdoor Exploratorium" experiences to exhibits. The project will culminate in a workbook for the field and two workshops for museum professionals. The Exploratorium Teacher Institute staff will develop two-week institutes that make extensive use of the "Outdoor Exploratorium." Classroom activities and inquiry-based learning experiences will be developed based on the new exhibits.
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TEAM MEMBERS:
Peter RichardsThomas HumphreyThomas RockwellTheodore KoterwasJoyce Ma
The James Agee Film Project is requesting funds to produce a four-part series of one-hour films on the environmental and social history of Appalachia. "APPALACHIA: A History of Mountains and People" will be the first series of films on the history of Appalachia and the first environmental history film ever made about a region in the United States. The project will demonstrate the dynamic interaction and inseparability of natural history and human history. By interweaving the discoveries and insights from scientific disciplines, including geology, ecology, biology and environmental science, with those of the humanities, the series will explore how the mountains have shaped human cultures and how people have shaped the mountains. "APPALACHIA: A History of Mountains and People" is made for national broadcast on PBS and is being co-sponsored by six Appalachian state PBS networks. The series is being produced in conjunction with the upcoming "Encyclopedia of Appalachia." Outreach programs include partnerships with many regional grassroots organizations, PBS stations and educational institutions to extend the film into a wide range of rural communities and schools. The Project Director/Writer of the series will be the Academy Award nominated filmmaker Ross Spears. Jamie Ross is co-producer/writer; Dr. George Constantz, the Science Writer/Content Director. Dr. Constantz is also currently the principal science and ecology editor of The Encyclopedia of Appalachia, which will be published in 2005. A distinguished group of scholars and scientists will contribute to the project. Dr. Gary Henry, Director of the Applied Research Center in Atlanta, will oversee the project evaluation.