Carnegie Museum of Natural History and the University of Pittsburgh are engaged in a research and practice partnership to bring new learning sciences findings and theories into contact with the design and deployment of innovative natural history learning experiences. In this article, we describe four strands of work: 1) connecting people to nature; 2) engaging people of all ages in complex and current scientific debates of regional consequence; 3) partnerships to build a strong regional learning ecology for nature and science; and 4) iterative professional development to support staff as they