This project will introduce students ages 8-14, including underserved students; their teachers and families; and the general public to three biomedical research areas inspired by NIH's Roadmap for Medical Research: biological pathways, bioinformatics and nanomedicine. These areas are unfamiliar to many adults and are not introduced in science curricula. Using the metaphor of a hardware store (i.e., building materials, tools, parts, home repair projects), the project will introduce families, students and teachers to three ideas: (1) The body maintains and repairs itself at the molecular, cell, tissue, organ and system levels; (2) Biomedical researchers are uncovering new complexities at the molecular level that can increase our understanding of how the body works; and (3) Developments in nanomedicine can lead to discoveries and treatments. In a hardware store theater and workshop space and in a virtual hardware store, the project will develop and present demonstrations and basic- and intermediate-level labs (for 2nd- and 6th-grade students or families); train museum staff and interns to present the programs; offer orientation workshops to teachers from Title I schools; develop a teacher's guide; conduct outreach in middle schools; engage scientists to talk about their work and help them communicate with the public; and create a manual of materials and activities for other science centers. The evaluation plan will include formative research on activities and assessment of how well repair metaphors facilitate understanding of clinical issues. A team of scientists, museum staff, science teachers, and biology and medical students will guide the development of education components.