The purpose of this paper is to examine the role of laboratory-based science from a perspective that synthesizes developments in (1) science studies, e.g., history, philosophy and sociology of science and (2) the learning sciences, e.g., cognitive science, philosophy of mind, educational psychology, social psychology, computer sciences, linguistics, and (3) educational research focusing on the design of learning environments that promote dynamic assessments. Taken together these three domains have reshaped our thinking about the role inquiry, and in turn the laboratory, has in science