Hexacago Health Academy (HHA) is a game-based science and health curriculum intervention. HHA engages high school students in learning about and addressing major sexual and reproductive health issues and risk behaviors. A board game, Hexacago, depicting the city of Chicago with an overlay of hexagons is the cornerstone of HHA. Students use the board design games and think critically about public health problems in the city of Chicago. HHA uses game-play, interaction with STEM science and health professionals, and mentoring to create a rich, game-based learning experience for high school students. The object of HHA is to improve academic performance, increase science and health career interest, and improve health behaviors among youth living in Chicago.