NSF's Cyberinfrastructure Vision for 21st Century Discovery is presented in a set of interrelated chapters that describe the various challenges and opportunities in the complementary areas that make up cyberinfrastructure: computing systems, data, information resources, networking, digitally enabled-sensors, instruments, virtual organizations, and observatories, along with an interoperable suite of software services and tools. This technology is complemented by the interdisciplinary teams of professionals that are responsible for its development, deployment and its use in transformative