In 2010, the NISE Network’s Diversity, Equity, and Access working group undertook a partnership pilot project to identify strategies for engaging youth from underrepresented backgrounds in nanoscale informal science learning experiences. To carry out the project, three museums developed partnerships to deliver programming at Boys & Girls Clubs in their communities. This report provides case studies of how the partnerships developed over time and provides lessons learned to help guide informal educators working with Boys & Girls Clubs or similar afterschool programs.